Synthesis and characterization of chitosan ascorbate nanoparticles for therapeutic inhibition for cervical cancer and their in silico modeling

This study focuses on synthesis and characterization of chitosan ascorbate nanoparticles (CANs) from a salified carboxylate form of chitosan with ascorbic acid. Evident changes were observed in crystallinity and structure of CANs from their parent polymer. CANs exhibited improved antioxidative properties against DPPH, ABTS, and FRAP. In vitro effect of CANs on cervical cancer cells (HeLa) and noncancer human fibroblast cells (WI-38) viability showed portentous toxic effects on cancer cells with reduced viability on increasing CANs concentration. However, no significant effect was observed in the fibroblast cells. Further, in snick:, docking on cervical cancer protein targets also showed efficient binding. (C) 2018 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights