Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 61, Issue -, Pages 340-347Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.12.032
Keywords
Digital light processing (DLP) 3D printing; Cell sedimentation; Solution viscosity; Silk fibroin particle; Gelatin-methacrylate (GelMA)
Funding
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) through the Agri-Bio Industry Technology Development Program - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [116077-03-2-HD020]
- Center for Food and Bioconvergence
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To improve the cell suspension of the gelatin-methacrylate(GelMA) bioink, the viscosity of the ink solution was controlled by biocompatible silk fibroin(SF) particles. The viscosity of the GelMA solution increased about 1.4 x 10(2) folds by the addition of 1 w/v% SF particles. The increase of solution viscosity reduced the displacement of cells and retarded the cell sedimentation significantly. SF-GelMA bioink containing 1 w/v% SF was non-cytotoxic and used for the 3D bioprinting by directly projecting a feature onto the bioink. The cells encapsulated in the structures showed a high level of metabolic activity and demonstrated that SF-GelMA was a biocompatible material. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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