Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 60, Issue -, Pages 250-258Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.11.011
Keywords
Multivalent; Aptamer; Nucleic acid structures; Delivery
Funding
- Global Innovative Research Center (GiRC) program through the National Research Foundation (NRF) [NRF-2012K1A1A2A01056094]
- Creative Materials Discovery Program through the National Research Foundation (NRF) [NRF-2014R1A2A1A11049772]
- Ministry of Education, Science and Technology, Republic of Korea
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To examine proper multivalency and type of aptamers in linear nucleic acid-based structures for efficient intracellular uptakes, we designed linear DNA structures with single and dual aptamers targeting guanosine-rich oligonucleotide 100 (AS1411) and mucin 1 (MUC-1). Multivalent linear DNA structures containing dual types of aptamers showed significantly superior cellular internalization. In addition, multivalent aptamer-immobilized DNA-RNA hybrid structures showed excellent tumor accumulation in vivo without liver toxicity and very low nonspecific cytokine induction. Thus, these multivalent nucleic acid based structures with dual types of aptamers can be specifically applied as carriers of therapeutic nucleic acids without inducing noticeable systemic toxicity. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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