Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 59, Issue -, Pages 266-276Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.10.032
Keywords
Magnesium hydroxide; Poly(lactic-co-glycolic acid) composites; Mechanical property; Anti-inflammation effect; Anti-bacterial activity
Funding
- Basic Science Research Program: through the National Research Foundation of Korea - Ministry of Science and ICT (MSIT) [2017R1A2B3011121]
- Bio & Medical Technology Development Program: through the National Research Foundation of Korea - Ministry of Science and ICT (MSIT) [2014M3A9D3033887]
- Next Generation Medical Device Platform Program: through the National Research Foundation of Korea - Ministry of Science and ICT (MSIT) [2015M3A9E2028580]
- Core Materials Technology Development Program - Ministry of Trade, Industry and Energy (MOTIE), Republic of Korea [10048019]
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Five different shapes of magnesium hydroxide (Mg(OH)(2)) particles (Plate-S, Plate-N, Disk, Whisker, and Fiber) were synthesized and added to biopolymer (i.e., Poly(lactic-co-glycolic acid) (PLGA)) composite to improve their mechanical and biological properties. The PLGA composite films including Mg(OH)(2) particles were prepared by a solvent casting method. Their mechanical and biological properties were compared according to the composites containing different shapes of Mg(OH)(2) particles. Among them; the fiber shape of Mg(OH)(2) provided the highest mechanical strength, and anti-inflammation and antibacterial activity to PLGA films among other forms. This study demonstrated a new strategy for the design of biomaterials by controlling the form of inorganic additives. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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