Journal
JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY
Volume 59, Issue -, Pages 184-191Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jiec.2017.10.022
Keywords
Inclined-GaN; Nanoneedle; Surface functionalization; Cell insertion; Intracellular delivery
Funding
- Ministry of Science, ICT, and Future Planning [NRF-2014M3A9E4064580]
- Advanced Biomass R&D Center (ABC) of the Global Frontier Project - Ministry of Science, ICT, and Future Planning [NRF-2015M3A6A2074238]
- Center for Advanced Meta-Materials (CAMM) - Ministry of Science, ICT and Future Planning as Global Frontier Project [CAMM-2014M3A6B3063716]
- KAIST-Kustar Institute
- NRF - MEST [2016R1A2B4010487]
- National Research Foundation of Korea [2016R1A2B4010487] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods, one-dimensional nanoneedles are one of the promising methods for insertion with minimal invasiveness to a cell. Most of the previous studies have been conducted using vertical nanoneedle. Here, we synthesized new inclined nanoneedles and demonstrated a novel platform using inclined-gallium nitride nanoneedles (iGaN NNs) to facilitate efficient intracellular delivery. In our system, foreign molecules were successfully delivered into cytoplasm of a cell through the penetration of the cell membrane by the iGaN NNs. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.
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