DETERMINATION OF METHIMAZOLE ON A MULTIWALL CARBON NANOTUBE TITANIUM DIOXIDE NANOPARTICLE PASTE ELECTRODE

A multiwall carbon nanotube titanium dioxide nanoparticle modified carbon paste electrode was used for direct determination of methimazole. The nanoparticles in the carbon paste increased the surface area of the electrode and improved the sensitivity by enhancing the peak current. The electrochemical behavior of methimazole on the modified electrode was investigated. Experimental variables such as pH and electrode composition were optimized. At the optimum pH 7.0 (universal buffer), the modified electrode had a linear dynamic range of 0.5 to 100.0mol L-1 (0.1-11.4ppm) with a limit of detection of 0.17mol L-1 . The application of the electrode for the determination of methimazole in pharmaceuticals and blood serum was investigated.