Journal
FEMS MICROBIOLOGY REVIEWS
Volume 38, Issue 2, Pages 172-184Publisher
OXFORD UNIV PRESS
DOI: 10.1111/1574-6976.12066
Keywords
cell cycle; homologous recombination; Saccharomyces cerevisiae; DNA end resection; post-translational regulation; transcriptional regulation
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Funding
- Danish Agency for Science, Technology and Innovation
- Villum Kann Rasmussen Foundation
- Lundbeck Foundation
- European Research Council (ERC) under the European Union/ERC [242905]
- European Research Council (ERC) [242905] Funding Source: European Research Council (ERC)
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Homologous recombination (HR) contributes to maintaining genome integrity by facilitating error-free repair of DNA double-strand breaks (DSBs) primarily during the S and G(2) phases of the mitotic cell cycle, while nonhomologous end joining (NHEJ) is the preferred pathway for DSB repair in G(1) phase. The decision to repair a DSB by NHEJ or HR is made primarily at the level of DSB end resection, which is inhibited by the Ku complex in G(1) and promoted by the Sae2 and Mre11 nucleases in S/G(2). The cell cycle regulation of HR is accomplished both at the transcription level and at the protein level through post-translational modification, degradation and subcellular localization. Cyclin-dependent kinase Cdc28 plays an established key role in these events, while the role of transcriptional regulation and protein degradation are less well understood. Here, the cell cycle regulatory mechanisms for mitotic HR in Saccharomyces cerevisiae are reviewed, and evolutionarily conserved principles are highlighted.
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