Journal
MEDICAL MYCOLOGY CASE REPORTS
Volume 5, Issue -, Pages 12-15Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mmcr.2014.04.002
Keywords
Candida kefyr; Kluyveromyces marxianus; ERG11; Single nucleotide polymorphism; Azole resistance
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We report on the first cloning and nucleotide sequencing of an ERG11 allele from a clinical isolate of Candida kefyr cross-resistant to azole antifungals. It was recovered from a stem cell transplant patient, in an oncohematology unit exhibiting unexpected high prevalence of C. kefyr. Two amino acid substitutions were identified: K151E, whose role in fluconazole resistance was already demonstrated in Candida albicans, and E123Q, a new substitution never described so far in azole-resistant Candida yeast. (C) 2014 The Authors. International Society for Human and Animal Mycology. Published by Elsevier B.V.
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