Journal
JOURNAL OF EXPERIMENTAL MEDICINE
Volume 215, Issue 4, Pages 1115-1133Publisher
ROCKEFELLER UNIV PRESS
DOI: 10.1084/jem.20171608
Keywords
-
Categories
Funding
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- PHENOMIN
- European Research Council [322465]
- Marie Sklodowska-Curie Actions [PIOF-GA-2013-625328-MeTaPATH]
- ERA-NET Infect-ERA (ABIR) [ANR-13-IFEC-0005-03]
- DCBIOL Labex [ANR-11-LABEX-0043, ANR-10-IDEX-0001-02 PSL]
- A*MIDEX project [ANR-11-IDEX-0001-02]
- ABIR project
- CelTisPhyBio LabEx as part of the IDEX PSL [ANR-10-LBX-0038]
- IDEX PSL [ANR-10-IDEX-0001-02 PSL]
Ask authors/readers for more resources
Here we describe a new mouse model that exploits the pattern of expression of the high-affinity IgG receptor (CD64) and allows diphtheria toxin (DT)-mediated ablation of tissue-resident macrophages and monocyte-derived cells. We found that the myeloid cells of the ear skin dermis are dominated by DT-sensitive, melanin-laden cells that have been missed in previous studies and correspond to macrophages that have ingested melanosomes from neighboring melanocytes. Those cells have been referred to as melanophages in humans. We also identified melanophages in melanocytic melanoma. Benefiting of our knowledge on melanophage dynamics, we determined the identity, origin, and dynamics of the skin myeloid cells that capture and retain tattoo pigment particles. We showed that they are exclusively made of dermal macrophages. Using the possibility to delete them, we further demonstrated that tattoo pigment particles can undergo successive cycles of capture-release-recapture without any tattoo vanishing. Therefore, congruent with dermal macrophage dynamics, long-term tattoo persistence likely relies on macrophage renewal rather than on macrophage longevity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available