Journal
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
Volume 37, Issue -, Pages -Publisher
BMC
DOI: 10.1186/s13046-018-0758-7
Keywords
Radiotherapy; Radioresistance; Metabolic pathway; Sensitivity; Cancer
Categories
Funding
- Overseas Expertise Introduction Project for Discipline Innovation (111 Project) [111-2-12]
- National Natural Science Foundation of China [81472531, 81472595, 81572787, 81672683, 81672993, 81672688, 81702907, 81772928]
- Natural Science Foundation of Hunan Province [2015JJ1022, 2016JC2035, 2017SK2105]
- Fundamental Research Funds for the Central South University [2016zzts478, 2014zzts066]
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Background: Radioresistance is a major factor leading to the failure of radiotherapy and poor prognosis in tumor patients. Following the application of radiotherapy, the activity of various metabolic pathways considerably changes, which may result in the development of resistance to radiation. Main body: Here, we discussed the relationships between radioresistance and mitochondrial and glucose metabolic pathways, aiming to elucidate the interplay between the tumor cell metabolism and radiotherapy resistance. In this review, we additionally summarized the potential therapeutic targets in the metabolic pathways. Short conclusion: The aim of this review was to provide a theoretical basis and relevant references, which may lead to the improvement of the sensitivity of radiotherapy and prolong the survival of cancer patients.
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