Journal
JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES
Volume 53, Issue 11, Pages 738-745Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/03601234.2018.1480161
Keywords
Chicken feed; chloramphenicol; magnetic molecularly imprinted polymers; microwave heating
Funding
- Center of Excellence for Innovation in Chemistry (PERCH-CIC Batch 14)
- Office of Higher Education Commission, Ministry of Education
- Kasetsart University Research and Development Institute (KURDI)
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A magnetic molecularly imprinted polymer (MMIP) for chloramphenicol was prepared using a surface-imprinted and microwave-heating-induced polymerization method. The surfaces of the magnetic particles were first double-bond functionalized with 3-(trimethoxysilyl)propyl methacrylate (gamma-MPS), followed by the copolymerization of 4-vinyl pyridine (4-VP) and trimethylolpropane trimethacrylate (TRIM) in the presence of chloramphenicol as a template and 1,1-azobis(cyclohexane-carbonitrile) (ABCN) as an initiator in a mixture of dimethyl sulfoxide and water with microwave heating at 80 degrees C. The magnetic polymer possesses supraparamagnetic properties and was used to concentrate and cleanup chicken feed extract, followed by chromatographic separation using a Lichrospher (R) 100 RP C8 column and detection with two multi-reaction monitoring transitions at m/z 321 -> 152 and m/z 321 -> 257. The mean recoveries obtained at two spiking levels were in the range of 94.6-100% The relative intra- and inter-day standard deviations were in the range of 1.4-2.6% and 5.1-5.7%, respectively. The detection limit of the method was 0.12 mu g kg(-1). This confirmatory method was successfully applied to determine chloramphenicol in chicken feed samples.
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