Journal
NATURE REVIEWS CANCER
Volume 14, Issue 7, Pages 495-501Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3767
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Funding
- US National Institutes of Health (NIH) for an Innovator Award [DP2OD002056-01, RO1 1R01GM102169-01]
- NIH Developmental Biology Training Grant [5T32 HDO7491]
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Metastasis is the leading cause of cancer-related deaths, but it is unclear how cancer cells escape their primary sites in epithelia and disseminate to other sites in the body. One emerging possibility is that transformed epithelial cells could invade the underlying tissue by a process called cell extrusion, which epithelia use to remove cells without disrupting their barrier function. Typically, during normal cell turnover, live cells extrude apically from the epithelium into the lumen and later die by anoikis; however, several oncogenic mutations shift cell extrusion basally, towards the tissue that the epithelium encases. Tumour cells with high levels of survival and motility signals could use basal extrusion to escape from the tissue and migrate to other sites within the body.
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