Journal
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
Volume 47, Issue -, Pages 159-166Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jddst.2018.07.010
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Funding
- National Eye Institute [1R01EY022120-01A1]
- National Institute of General Medical Sciences, National Institutes of Health [P20GM104932]
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The current study sought to formulate, optimize, and evaluate curcumin-loaded Nanostructured Lipid Carriers (NLCs) for their in vitro and ex vivo characteristics. NLCs, prepared using hot-melt emulsification and ultrasonication techniques, were optimized using a Central Composite Design (CCD) and evaluated for their in vitro physicochemical characteristics. Their stability over a 3 month period and transcorneal permeation across excised rabbit corneas (ex vivo) were assessed for the optimized NLCs. The optimized NLC, with a particle size of 66.8 +/- 2 nm, polydispersity index of 0.17 +/- 0.05, entrapment efficiency of 96 +/- 1.6%, and drug loading of 3.1 +/- 0.05% w/w, was chosen using CCD. The optimized NLCs showed optimum ex vivo stability at 4 degrees C for the study period and demonstrated a significant increase in curcumin permeation (similar to 2.5-fold) across the rabbit cornea in comparison to the control. Overall, these studies indicated the successful development of NLCs using the design of experiment approach; the formulation enhanced curcumin permeation across excised corneas and did not show any harmful side effects.
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