Journal
NATURE REVIEWS CANCER
Volume 14, Issue 8, Pages 547-558Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrc3773
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Funding
- University of Cambridge
- Cancer Research UK
- Hutchison Whampoa
- Human Frontier Science Program
- Cancer Research UK [15890] Funding Source: researchfish
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The core aspect of the senescent phenotype is a stable state of cell cycle arrest. However, this is a disguise that conceals a highly active metabolic cell state with diverse functionality. Both the cell-autonomous and the non-cell-autonomous activities of senescent cells create spatiotemporally dynamic and context-dependent tissue reactions. For example, the senescence-associated secretory phenotype (SASP) provokes not only tumour-suppressive but also tumour-promoting responses. Senescence is now increasingly considered to be an integrated and widespread component that is potentially important for tumour development, tumour suppression and the response to therapy.
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