Journal
JOURNAL OF DERMATOLOGICAL SCIENCE
Volume 89, Issue 2, Pages 112-119Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.jdermsci.2017.11.006
Keywords
Skin lipid; Skin status; Microecology; Lipidomics
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Funding
- National Natural Science Foundation of China [31501415]
- Science and Technology Planning Project of Beijing [Z171100001517006]
- Scientific Research Project of Beijing Educational Committee [SQKM201610011008]
- China Cosmetic Collaborative and Innovation Center, BTBU [19008001060]
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Skin lipids, compose of sebocyte-, keratinocyte-, and microbe-derived lipids, dramatically influence skin status by different mechanisms. (I) Physical chemistry function: They are mortar to establish the physico-chemical barrier function of skin; (II) Biochemistry function: They function as signals in the complex signaling network originating at the epidermal level; (III) Microecology function: Sebocyte- and keratinocyte-derived lipids vary the composition of microbial skin flora, and microorganisms metabolize them to produce lipids as signal starting signaling transduction. Importantly, further research needs lipidiomics, more powerful analytical ability and high-throughput manner, to identify skin lipid components into individual species. The validation of lipid structure and function to research the process that lipid species involved in. Additional, the integration of lipidomics data with other omics strategies can develop the power to study the mechanism of skin lipids influencing skin status. (C) 2017 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
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