Journal
JOURNAL OF DENTAL RESEARCH
Volume 97, Issue 7, Pages 742-750Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0022034518756297
Keywords
squamous cell carcinoma; prognosis; metastasis; neoplasm recurrence; neurotrophic factors; galanin
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Perineural invasion (PNI) is a mechanism of tumor dissemination that can provide a challenge to tumor eradication and that is correlated with poor survival. Squamous cell carcinoma, the most common type of head and neck cancer, has a high prevalence of PNI. This review provides an overview of clinical studies on the outcomes and factors associated with PNI in head and neck cancer and on findings on cancer-nerve crosstalk.
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