Journal
JOURNAL OF CYSTIC FIBROSIS
Volume 17, Issue 6, Pages 783-790Publisher
ELSEVIER
DOI: 10.1016/j.jcf.2018.03.008
Keywords
Cystic fibrosis related diabetes; Continuous glucose monitoring; Pediatrics
Categories
Funding
- NUT [DK094712-04, TR000154, UL1 TR001082]
- Cystic Fibrosis Foundation Therapeutics grant [CHAN16A0]
- National Institute of Diabetes And Digestive And Kidney Diseases of the National Institutes of Health
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Background: To characterize glucose patterns with continuous glucose monitoring (CGM) in cystic fibrosis (CF) and assess relationships between CGM and clinical outcomes. Methods: 110 CF youth and healthy controls (BC), 10-18 years, wore CGM up to 7 days. Correlations between CGM and lung function and BMI z-score change over the prior year were determined. Results: Multiple CGM measures were higher in CF Normal Glycemic (CFNG) youth versus HC (peak glucose, excursions >140 mg/dl/day, % time > 140 mg/dl, standard deviation (SD) and mean amplitude of glycemic excursions (MAGE)). Hypoglycemia was no different among groups. In CF, decline in FEV 1% and FVC% correlated with maximum CGM glucose, excursions >200 mg/dl/day, SD, and MAGE. Conclusions: CFNG youth have higher glucoses and glucose variability than HC on CGM. Higher and more variable glucoses correlate with lung function decline. Whether earlier treatment of CGM abnormalities improves lung function in CF requires further study. (C) 2018 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
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