Journal
PSEUDOGENES: FUNCTIONS AND PROTOCOLS
Volume 1167, Issue -, Pages 213-226Publisher
HUMANA PRESS INC
DOI: 10.1007/978-1-4939-0835-6_14
Keywords
Pseudogene; Antisense RNA; Noncoding RNA; Epigenetics; Transcriptional regulation; DNMT3A; EZH2; RNA stability
Funding
- NIAID NIH HHS [P01 AI099783-01] Funding Source: Medline
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While long thought to represent only junk DNA, several recent studies support a functional role for pseudogenes. Several hundreds of pseudogenes have been reported as transcribed into RNA in a large variety of tissues and tumors. Most studies have focused on pseudogenes expressed in the sense direction, but some reports suggest that pseudogenes can be also transcribed as antisense RNAs (asRNAs). A few examples of key regulatory genes, such as PTEN and OCT4, have in fact been reported to be under the regulation of pseudogene-expressed asRNAs. Here, we review what is known about pseudogene-expressed asRNAs and we discuss the functional role that these transcripts may have in gene regulation. Finally, we discuss some technical challenges when characterising the function of pseudogene asRNAs.
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