Cost Effective, Green Synthesis of Copper Oxide Nanoparticles Using Fruit Extract of Syzygium alternifolium (Wt.) Walp., Characterization and Evaluation of Antiviral Activity

The present study was aimed to synthesize copper oxide nanoparticles (CuO NPs) using fruit extract of Syzygium alternifolium and to evaluate their antiviral activity against Newcastle Disease Virus (NDV). The CuO NPs synthesized, were characterized by employing different spectroscopic and microscopic tools. The peak manifested at 285 nm in UV-Vis analysis confirms the synthesis of CuO NPs. FTIR analysis showed two conspicuous peaks at 3253 and 1461 cm(-1) which correspond to O-H stretch of phenols and N-H bond of primary amines of proteins respectively. This result confirms their involvement in capping and stabilization of nanoparticles. The DLS and zeta potential studies revealed 61.1 nm average size and - 49.2 mV of zeta potential (zeta) value. The XRD crystallography investigations exhibited end-centered monoclinic crystalline nature nanoparticles with 17.5 nm average size. The microscopic (AFM, SEM, TEM) analyses unveiled spherical shaped particles with 2-69 nm size of the CuO NPs. These nanoparticles were settled in poly-dispersed and non-agglomerated state. They exhibited potential growth inhibitory effect on NDV virus. Based on the results of present work it can be emphasized that nanoparticles synthesized using plant extracts find a place in future nanomedicine.