Journal
JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY
Volume 38, Issue 3, Pages 247-249Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/JCP.0000000000000859
Keywords
alpha 7 nAChR; cognition; nicotinic; schizophrenia
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Purpose: The aim of this article is to review the recent trials of alpha 7 nicotinic acetylcholine receptor (alpha 7 nAChR) agonists and positive allosteric modulators (PAMs) on the treatment of cognitive decline in schizophrenia alpha 7 Nicotinic acetylcholine receptor abnormalities in schizophrenia and clinical implications of alpha 7 nAChR agonists and PAMs are also discussed. Procedures: Studies were searched on PubMed with keywords nicotinic, alpha7, and schizophrenia over a 2-year period: January 1, 2016, to December 1, 2017. Cognition was not included in key terms in order to broaden the results. Inclusion criteria included (1) article categorization as a clinical study, review, or journal article; (2) schizophrenia diagnosis based on Diagnostic and Statistical Manual of Mental Disorders criteria; (3) article in English; (4) objective measure of cognition from effects of alpha 7 nAChR agonists/PAMs; and (5) article currently published. Findings: A total of 76 studies were found over the past 2 years. Fifteen of these studies were included in this review. Human studies were limited. Cognitive-related improvements in rodent models were found across the 6 cognitive constructs: perception, executive functioning, social and affective processes, working memory, and long-term memory.
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