Journal
CANCER GENOMICS AND PROTEOMICS: METHODS AND PROTOCOLS, 2ND EDITION
Volume 1176, Issue -, Pages 89-106Publisher
HUMANA PRESS INC
DOI: 10.1007/978-1-4939-0992-6_8
Keywords
Homologous recombination; Mutagenesis; Peptide nucleic acid (PNA); Triplex; Triplex-forming oligonucleotide (TFO); Site-specific gene editing
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Funding
- NIBIB NIH HHS [R01 EB000487] Funding Source: Medline
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Triplex-forming oligonucleotides (TFOs) are capable of coordinating genome modification in a targeted, site-specific manner, causing mutagenesis or even coordinating homologous recombination events. Here, we describe the use of TFOs such as peptide nucleic acids for targeted genome modification. We discuss this method and its applications and describe protocols for TFO design, delivery, and evaluation of activity in vitro and in vivo.
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