Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 1, Pages 54-63Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI93558
Keywords
-
Categories
Funding
- Institut Pasteur
- Institut National de la Sante et de la Recherche Medicale (INSERM)
- European Research Council [648428-PERIF]
Ask authors/readers for more resources
The ability to repair tissues is essential for the survival of organisms. In chronic settings, the failure of the repair process to terminate results in overproduction of collagen, a pathology known as fibrosis, which compromises organ recovery and impairs function. The origin of the collagen-overproducing cell has been debated for years. Here we review recent insights gained from the use of lineage tracing approaches in several organs. The resulting evidence points toward specific subsets of tissue-resident mesenchymal cells, mainly localized in a perivascular position, as the major source for collagen-producing cells after injury. We discuss these findings in view of the functional heterogeneity of mesenchymal cells of the perivascular niche, which have essential vascular, immune, and regenerative functions that need to be preserved for efficient repair.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available