Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 1, Pages 85-96Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI93562
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Funding
- Wellcome Trust Four-Year PhD Studentship
- Stem Cell Biology and Medicine Programme
- Wellcome Cambridge Trust Scholarship
- Wellcome Trust [104151/Z/14/Z]
- Royal Society [104151/Z/14/Z]
- H grant
- Wellcome Trust [104151/Z/14/Z] Funding Source: Wellcome Trust
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Epithelial cell loss alters a tissue's optimal function and awakens evolutionarily adapted healing mechanisms to reestablish homeostasis. Although adult mammalian organs have a limited regeneration potential, the liver stands out as one remarkable exception. Following injury, the liver mounts a dynamic multicellular response wherein stromal cells are activated in situ and/or recruited from the bloodstream, the extracellular matrix (ECM) is remodeled, and epithelial cells expand to replenish their lost numbers. Chronic damage makes this response persistent instead of transient, tipping the system into an abnormal steady state known as fibrosis, in which ECM accumulates excessively and tissue function degenerates. Here we explore the cellular and molecular switches that balance hepatic regeneration and fibrosis, with a focus on uncovering avenues of disease modeling and therapeutic intervention.
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