Journal
JOURNAL OF CLINICAL INVESTIGATION
Volume 128, Issue 7, Pages 2757-2759Publisher
AMER SOC CLINICAL INVESTIGATION INC
DOI: 10.1172/JCI121653
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- NIDA [DA025983]
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The ability to recognize and avoid noxious stimuli is essential for survival. The factors that determine whether a given stimulus is considered positive or negative are complex and not fully understood. In this issue of the JCI, Klawonn and colleagues demonstrate that melanocortin 4 receptor (MC4R) signaling is critical for proper responses to negative stimuli. Mice lacking MC4R were shown to have a surprising preference for aversive stimuli compared with WT animals. Moreover, the authors provide evidence that avoidance behaviors are mediated by hypothalamic POMC neurons signaling to striatal dopamine D1 receptor-expressing medium spiny neurons. Together, these results provide important insight into the regulation of responses to aversive stimuli.
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