Journal
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
Volume 103, Issue 7, Pages 2592-2600Publisher
ENDOCRINE SOC
DOI: 10.1210/jc.2018-00184
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Funding
- Ministry of Social Affairs and Health of Finland
- Ministry of Education and Culture of Finland
- Finnish Innovation Fund Sitra
- Social Insurance Institution of Finland
- Finnish Cultural Foundation
- Juho Vainio Foundation
- Foundation for Pediatric Research
- Paulo Foundation
- Paavo Nurmi Foundation
- Diabetes Research Foundation
- Yrjo Jahnsson Foundation
- Finnish Foundation for Cardiovascular Research
- Research Committee of Kuopio University Hospital Catchment Area (State Research Funding)
- Kuopio University Hospital [5031343]
- Finnish Medical Foundation
- Paivikki and Sakari Sohlberg Foundation
- Rauha and Jalmari Ahokas Foundation
- city of Kuopio
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Context: Premature adrenarche (PA) has been associated with overweight and insulin resistance, but the associations of serum dehydroepiandrosterone sulfate (DHEAS) concentration with other cardiometabolic risk factors are uncertain. Objective: To examine the associations of serum DHEAS concentration with several cardiometabolic risk factors in children. Design: Cross-sectional data from the Physical Activity and Nutrition in Children Study. Participants: Population sample of 207 girls and 225 boys aged 7.6 +/- 0.4 years. Main Outcome Measures: Cardiometabolic risk factors by serum DHEAS concentration. Results: DHEAS correlated positively with body mass index standard deviation score, body fat percentage, lean body mass, high-sensitivity C-reactive protein (hs-CRP), and alanine aminotransferase (ALT) when adjusted for age and sex. The associations of DHEAS with hs-CRP andALT disappeared when adjusted also for body fat percentage. When further adjusted for birthweight SD score, DHEAS correlated negatively with low-density lipoprotein (LDL) cholesterol and LDL/high-density lipoprotein (HDL) cholesterol ratio. LDL cholesterol was lower in children with DHEAS >= 40 mg/dL than in those with DHEAS,40 mg/dL, adjusted for age, sex, and body fat percentage (86.5 vs 92.3 mg/dL, P = 0.029). This association strengthened after further adjustment for birth weight SD score (85.3 vs 92.3mg/dL, P = 0.012). Conclusion: Higher DHEAS is not associated with an increased cardiometabolic risk in prepubertal children. Instead, it may be protective, evidenced by an association with lower LDL cholesterol and LDL/HDL cholesterol ratio. The increased cardiometabolic risk in PA shown in many studies may be due to low birth weight and childhood overweight associated with PA.
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