Parity Increases Insulin Requirements in Pregnant Women With Type 1 Diabetes

Context: Tight glycemic control throughout pregnancy in women with type 1 diabetes is crucial, and knowledge about which factors that affect insulin sensitivity could improve the outcome for both mother and offspring. Objective: To evaluate insulin requirements in women with type 1 diabetes during pregnancy and test whether parity affects insulin requirements. Design: Observational cohort study consisting of women with type 1 diabetes who gave birth at Aarhus University Hospital, Denmark, from 2004 to 2014. Main Outcome Measure: Daily insulin requirement (the hypothesis that parity could affect insulin resistance was formulated before data collection). Results: A total of 380 women with a total of 536 pregnancies were included in the study. Mean age was 31.1 years, and prepregnancy hemoglobin A1c was 60 mmol/mol. Parity was as follows: P0, 43%; P1, 40%; P2, 14%; and P3+4, 3%. Insulin requirements from weeks 11 to 16 decreased significantly by 4% (P = 0.0004) and rose from week 19 to delivery with a peak of 70% (P<0.0005) at weeks 33 to 36. Overall, insulin requirements increased significantly with parity. The unadjusted differences between P0 and P1, P2, and P3+ 4 were 9% (P<0.0005), 12% (P<0.0005), and 23% (P<0.0011), respectively. After adjustment for confounders, differences were 13% (P<0.0005), 20% (P, 0.0005), and 36% (P<0.0005). We also observed an adjusted difference between P1 and P3+ 4 of 20% (P, 0.0012). Conclusions: The data show changes in insulin requirements from week to week in pregnancy and indicate that insulin requirements increase with parity. This suggests that the patient's parity probably should be considered in choosing insulin dosages for pregnant women with type 1 diabetes.