Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1546, Issue -, Pages 1-9Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2018.02.060
Keywords
Endocrine disrupting chemicals; Parabens; UV-filters; Human milk; QuECHERS; UHPLC-MS/MS
Funding
- European Union Commission (H2020-EJP-HBM4EU)
- Institute of Health Carlos III - Spanish Ministry of Health (Biomedical Research Networking Center CIBERESP) [FIS-PI16/01820, FIS-PI16/01812, FIS-PI16/01858]
- Spanish Ministry of Economy and Competitiveness [FJCI-2014-19698]
- European Union Commission [SOE1/P1/F0082]
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Concerns are growing about human exposure to endocrine disrupting chemicals (EDCs), especially during developmental stages. Parabens (PBs) and ultraviolet filters (UVFs) are prevalent EDCs widely used as additives in cosmetics and personal care products (PCPs). The objective of this study was to develop a method to determine four PBs and ten UVFs in human milk using QuEChERS treatment and ultra-high performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). Multivariate strategies were applied to optimize experimental parameters. Limits of quantification ranged from 0.1 to 0.2 ng mL(-1) and inter-day variability (evaluated as relative standard deviation) from 6% to 13%. The method was validated using matrix-matched standard calibration followed by a recovery assay with spiked samples. Recovery percentages ranged from 87% to 112%. The method was satisfactorily applied to assess target compounds in human milk samples from 15 donors. This analytical procedure can provide information on newborn exposure to these EDCs. (C) 2018 Elsevier B.V. All rights reserved.
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