Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1545, Issue -, Pages 48-58Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2018.02.053
Keywords
Zirconium-89; ImmunoPET; Medical isotope; Automation; Anion exchange; Fluoride complexation
Funding
- U.S. Department of Energy Office of Science, Isotope Development and Production for Research and Applications (IDPRA) subprogram of the Office of Nuclear Physics
- U.S. Department of Energy [DE-AC06-67RLO 1830]
- National Institute of Health [S10-RR017229]
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Zirconium-89 (Zr-89), produced by the (p, n) reaction from naturally monoisotopic yttrium (Y-nat), is a promising positron emitting isotope for immunoPET imaging. Its long half-life of 78.4h is sufficient for evaluating slow physiological processes. A prototype automated fluidic system, coupled to on-line and in-line detectors, has been constructed to facilitate development of new Zr-89 purification methodologies. The highly reproducible reagent delivery platform and near-real time monitoring of column effluents allows for efficient method optimization. The separation of Zr from dissolved Y metal targets was evaluated using several anion exchange resins. Each resin was evaluated against its ability to quantitatively capture Zr from a load solution high in dissolved Y. The most appropriate anion exchange resin for this application was identified, and the separation method was optimized. The method is capable of a high Y decontamination factor (>10(5)) and has been shown to remove Fe, an abundant contaminant in Y foils, from the Zr-89 elution fraction. Finally, the method was evaluated using cyclotron bombarded Y foil targets; the method was shown to achieve >95% recovery of the Zr-89 present in the foils. The anion exchange column method described here is intended to be the first Zr-89 isolation stage in a dual-column purification process. (C) 2018 Elsevier B.V. All rights reserved.
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