Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1559, Issue -, Pages 178-185Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.11.068
Keywords
Ionic liquid; Cyclodextrin derivative; Capillary electrophoresis; Enantioseparation; Molecular docking
Funding
- National Natural Science Foundation of China [81373378]
- Natural Science Foundation of Jiangsu Province [BK20150697, BK20141353]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Recently,ionic liquids (ILs) functionalized cyclodextrins (CDs) have attracted more and more attention in the fields of enantioseparation. In this study, a novel IL amino triazolium functionalized beta-CD derivative, mono-6-deoxy-6-(4-amino-1,2,4-triazolium)-beta-cyclodextrin chloride (4-ATMCDCI), was synthesized for the first time and managed to separate dansyl amino acids and naproxen by capillary electrophoresis (CE). Compared with native beta-CD, the new selector exhibited good water solubility and enhanced enantioselectivity. Several crucial parameters such as selector concentration, buffer pH, and applied voltage were systematically investigated. The molecular docking program Autodock was applied to further demonstrate the mechanism of chiral recognition and the enhanced enantioselectivity of 4-ATMCDCI, which showed good agreement with our experimental results. (C) 2017 Elsevier B.V. All rights reserved.
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