Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1553, Issue -, Pages 25-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2018.04.018
Keywords
Chlorophenols; TOPSIS; Experimental design; Microextraction; Method optimization; MCDA
Funding
- Ministry of Science and Higher Education under Iuventus Plus program [IP2014 048173]
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A novel and efficient approach to optimization of extraction step prior the chromatographic determination of nine chlorinated phenols is described. It is based on the combination of design of experiments and multicriteria decision analysis. Such an approach is used to optimize dispersive liquid-liquid microextraction procedure for the determination of 9 chlorophenols in water samples. Three parameters are optimized - sample volume, volume of disperser solvent and extraction solvent. Combination of the technique for order of preference by similarity to ideal solution with central composite design allows to perform multi-analyte procedure optimization. It gives information about the efficiency of the system for every experimental plan point in terms of closeness to ideal solution. The optimal conditions for extraction of chlorophenols are 76 mu L of extraction solvent, 0.6 mL of dispersive solvent and 6.7 mL of water sample. The presented approach has the potential to be applied in variety of optimization systems. (C) 2018 Elsevier B.V. All rights reserved.
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