Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1559, Issue -, Pages 170-177Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.chroma.2017.06.007
Keywords
Chiral ionic liquid; Synergistic system; Capillary electrophoresis; Enantioseparation; Molecular docking
Funding
- Project of National Natural Science Foundation of China [81373378]
- Natural Science Foundation of Jiangsu Province [BK20150697]
- Project of the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
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Discovering more superior performance of ionic liquids for the separation science has triggered increasing interest. In this work, two new Hydroxy acid-based chiral ionic liquids (CILs) (tertramethylammonium-Dpantothenate (TMA-D-PAN), tertramethylammonium-D-quinate (TMA-D-QUI)) were designed and first used as additives to establish the maltodextrin-based synergistic systems for enantioseparation in capillary electrophoresis (CE). Compared to traditional single maltodextrin chiral separation system, significantly improved separations of all tested drugs in the CIL/Maltodextrin synergistic systems were obtained. Some parameters (CIL concentration, maltodextrin concentration, buffer pH, and applied voltage) in the TMA-D-PAN/Maltodextrin synergistic system have been examined and optimized for analytes. The molecular docking software AutoDock was applied to simulate the recognition process and surmise feasible resolution mechanism in the Maltodextrin/CILs synergistic systems, which has certain guiding value. (C) 2017 Elsevier B.V. All rights reserved.
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