Journal
JOURNAL OF CHROMATOGRAPHIC SCIENCE
Volume 56, Issue 4, Pages 376-381Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/chromsci/bmy006
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Funding
- Medical University of Silesia [KNW-1-006/K/6/O]
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The lipophilicity of new two series of anticancer active 10-substituted 1,6- and 3,6-diazaphenothiazines has been investigated using reversed-phase thin-layer chromatography. Their lipophilicity (R-M0 and log P-TLC) was determined with mixtures of acetone and Tris buffer as mobile phases. The relative lipophilicity parameter R-M0 and specific hydrophobic surface area b were significantly intercorrelated showing congeneric classes of diazaphenothiazines. The parameter R-M0 was transformed into parameter log P-TLC by use of the calibration curve. The parameter log P-TLC was compared with computationally calculated lipophilic parameters log P-calcd. The lipophilicity was discussed with the structure elements and was correlated with molecular descriptors, ADME properties and in vitro anticancer activities.
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