Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 39, Issue 10, Pages 2089-2095Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X18780602
Keywords
Cerebral blood flow; cerebrovascular reactivity; functional magnetic resonance imaging; hypoxia; neurovascular coupling
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Funding
- MRC [G0901948, MR/K026739/1] Funding Source: UKRI
- Wellcome Trust [204624/Z/16/Z, 200893/Z/16/Z] Funding Source: Wellcome Trust
- British Heart Foundation [RG/14/4/30736, RG/15/15/31742] Funding Source: Medline
- Medical Research Council [G0901948, MR/K026739/1] Funding Source: Medline
- Wellcome Trust [204624/Z/16/Z, 200893/Z/16/Z] Funding Source: Medline
- Department of Health Funding Source: Medline
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K(IR)6.1 (KCNJ8) is a subunit of ATP sensitive potassium channel (K-ATP) that plays an important role in the control of peripheral vascular tone and is highly expressed in brain contractile cells (vascular smooth muscle cells and pericytes). This study determined the effect of global deletion of the K(IR)6.1 subunit on cerebral blood flow, neurovascular coupling and cerebral oxygenation in mice. In K(IR)6.1 deficient mice resting cerebral blood flow and brain parenchymal partial pressure of oxygen (PO2) were found to be markedly lower compared to that in their wildtype littermates. However, cortical blood oxygen level dependent responses triggered by visual stimuli were not affected in conditions of K(IR)6.1 deficiency. These data suggest that K-ATP channels containing K(IR)6.1 subunit are critically important for the maintenance of normal cerebral perfusion and parenchymal PO2 but play no significant role in the mechanisms underlying functional changes in brain blood flow.
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