Journal
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
Volume 39, Issue 8, Pages 1613-1622Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/0271678X18761438
Keywords
White matter hyperintensities; DTI; FDG-PET; longitudinal analysis; lesion classification
Categories
Funding
- National Key Research and Development Program of China [2016YFC1306600]
- Fundamental Research Funds for the Central University [2017XZZX001-01]
- Zhejiang Provincial Natural Science Foundation of China [LZ14H180001, LY16H090010]
- Alzheimer's Disease Neuroimaging Initiative (ADNI) (National Institutes of Health Grant) [U01 AG024904]
- DOD ADNI (Department of Defense award) [W81XWH-12-2-0012]
- National Institute on Aging, the National Institute of Biomedical Imaging and Bioengineering
- AbbVie
- Alzheimer's Association
- Alzheimer's Drug Discovery Foundation
- Araclon Biotech
- Bio Clinica, Inc.
- Biogen
- Bristol-Myers Squibb Company
- Cere Spir, Inc.
- Eisai Inc.
- Elan Pharmaceuticals, Inc.
- Eli Lilly and Company
- Euro Immun
- F. Hoffmann-La Roche Ltd and its affiliated company Genentech, Inc.
- Fujirebio
- GE Healthcare
- IXICO Ltd.
- Janssen Alzheimer Immunotherapy Research & Development, LLC
- Johnson & Johnson Pharmaceutical Research & Development LLC
- Lumosity
- Lundbeck
- Merck Co., Inc.
- MesoScale Diagnostics, LLC
- NeuroRx Research
- Neurotrack Technologies
- Novartis Pharmaceuticals Corporation
- Pfizer Inc.
- Piramal Imaging
- Servier
- Takeda Pharmaceutical Company
- Transition Therapeutics
- Canadian Institutes of Health Research
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Our purpose is to evaluate the microstructural and metabolism property in the white matter that later become white matter hyperintensity (WMH), and of WMH that later disappeared. Forty subjects with two-year follow-up were included. Each subject had 3DT1, T2FLAIR, DTI and FDG-PET scans. White matter was classified into: constant WMH, growing WMH, shrinking WMH and normal appearing white matter (NAWM). The average DTI (FA and MD) and FDG-PET (standardized FDG-PET rSUV) of each of the above-mentioned region were extracted and compared. At baseline, the growing WMH had lower FA and FDG-PET rSUV than NAWM, but had higher FA than the constant WMH. Longitudinally, in NAWM, there was a more rapid decline in metabolism compared to WMH areas, while in the growing WMH, a progression in diffusion was found. Finally, we discovered that the shrinking WMH had a similar microstructural and metabolism property and progression to the constant WMH. Our results suggest there are dynamic changes in microstructural and metabolism in WMH. The metabolic change was mainly found in NAWM, while the microstructural change was mainly found in WMH region. Besides, the reduced volume in WMH, to a larger extent, is irrelevant to the microstructural or metabolism recovery.
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