Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 233, Issue 8, Pages 5523-5529Publisher
WILEY
DOI: 10.1002/jcp.26348
Keywords
central nervous system; multiple sclerosis; myelination; pericytes
Categories
Funding
- National Cancer Institute [1R01CA179072-01A1]
- American Cancer Society [124443-MRSG-13121]
- Serrapilheira Institute [G-1708-15285]
- Pro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG) [Edital 05/2016]
- FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular, REMETTEC] [RED-00570-16]
- FAPEMIG [Rede De Pesquisa Em Doencas Infecciosas Humanas E Animais Do Estado De Minas Gerais] [RED-00313-16]
- National Institute of Health [1R01CA179072-01A1]
- American Cancer Society Mentored Research Scholar [124443-MRSG-13-121-01-CDD]
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Multiple sclerosis is a highly prevalent chronic demyelinating disease of the central nervous system. Remyelination is the major therapeutic goal for this disorder. The lack of detailed knowledge about the cellular and molecular mechanisms involved in myelination restricts the design of effective treatments. A recent study by using [De La Fuente et al. (2017) Cell Reports, 20(8): 1755-1764] by using state-of-the-art techniques, including pericyte-deficient mice in combination with induced demyelination, reveal that pericytes participate in central nervous system regeneration. Strikingly, pericytes presence is essential for oligodendrocyte progenitors differentiation and myelin formation during remyelination in the brain. The emerging knowledge from this research will be important for the treatment of multiple sclerosis.
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