Journal
JOURNAL OF CELLULAR PHYSIOLOGY
Volume 233, Issue 10, Pages 6425-6439Publisher
WILEY
DOI: 10.1002/jcp.26461
Keywords
fates; macrophages; monocytes; ontogeny; origin
Categories
Funding
- National Key Research and Development Program of China [2017YFA0105002, 2017YFA0104402]
- Knowledge Innovation Program of Chinese Academy of Sciences [XDA04020202-19]
- China Manned Space Flight Technology Project [TZ-1]
- CAS/SAFEA International Partnership Program for Creative Research Teams
- National Natural Science Foundation for General and Key Programs [C81530049, C81130055, C31470860, 81571563]
Ask authors/readers for more resources
Monocytes and macrophages are critical effectors and regulators of innate immune response. They not only play crucial and distinctive roles in homeostasis, but also contribute to some pathologic processes. The heterogeneity of the macrophage lineage has been widely recognized and, in part, is a result of the specialization of resident macrophages in particular tissue microenvironments. Monocytes are usually known to originate in the bone marrow from a common myeloid progenitor that is shared with neutrophils, and they are then released into the peripheral blood. However, the origin of tissue-resident macrophages, crucial for homeostasis and immunity, has remained controversial until recently. During embryonic organogenesis, macrophages derived from yolk sac and fetal liver precursors are seeded throughout tissues, persisting in the adulthood as resident, self-maintaining populations. After birth, bone marrow-derived monocytes can replenish tissue resident macrophages following injury, infection and inflammation. In this review, we will mainly summarize our current understanding on the origin, ontogeny and fates of tissue macrophages and will briefly discuss the molecular regulation of resident macrophage homeostasis in physiological situation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available