Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 119, Issue 6, Pages 4897-4906Publisher
WILEY
DOI: 10.1002/jcb.26717
Keywords
clonal amplification; clonal integration; oncovirus; tumor virus; whole-genome sequencing (WGS)
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Funding
- American Cancer Society [126773-IRG 14-196-01]
- University of Vermont (Start-up Fund of The University of Vermont)
- Lion Heart Fund (Lion Heart Fund for Breast Cancer Research)
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Oncoviruses contribute significantly to cancer burden. A century of tumor virological studies have led to the discovery of seven well-accepted human oncoviruses, cumulatively responsible for approximately 15% of human cancer cases. Virus-caused cancers are largely preventable through vaccination. Identifying additional oncoviruses and virus-caused tumors will advance cancer prevention and precision medicine, benefiting affected individuals, and society as a whole. The historic success of finding human oncoviruses has provided a unique lesson for directing new research efforts in the post-sequencing era. Combing the experiences from these pioneer studies with emerging high-throughput techniques will certainly accelerate new discovery and advance our knowledge of the remaining human oncoviruses.
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