Journal
JOURNAL OF CELLULAR BIOCHEMISTRY
Volume 119, Issue 6, Pages 4279-4286Publisher
WILEY
DOI: 10.1002/jcb.26645
Keywords
cancer; inhibitory receptors; reversal; T cell exhaustion; treatment strategy
Categories
Funding
- Jiangsu Students' Fund Project for Innovation and Entrepreneurship Training Program [201710312001Z]
- National Natural Science Foundation of China [81772596]
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During chronic viral infection or cancer, the immune system usually induces a corresponding immune response against pathogens or cancer cells so as to prevent worsening disease. T cell exhaustion in which reduced and dysfunctional effector T cells lead to immune escape is one of the mechanisms that pathogens or cancer cells get rid of control from the immune system. In this review, we discuss some mechanisms associated with T cell exhaustion and enumerate current methods of reversing T cell exhaustion. We also summarize current targeted treatment strategies and put forward following aspects that required to research. T cell exhaustion in which reduced and dysfunctional effector T cells lead to immune escape is one of the mechanisms that pathogens or cancer cells get rid of control from the immune system. In this review, we discuss some mechanisms associated with T cell exhaustion and enumerate current methods of reversing T cell exhaustion. We also summarize current targeted treatment strategies and put forward following aspects that required to research.
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