Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume 22, Issue 4, Pages 2510-2513Publisher
WILEY
DOI: 10.1111/jcmm.13516
Keywords
wound healing; tissue regeneration; scarring; hypertrophic scarring; fibromodulin
Categories
Funding
- Plastic Surgery Foundation(R) [269698]
- NIH-NIAMS [R44AR064126]
- NIH-NIDCR [R44DE024692, R44DE026080, SB1DE026972]
- NIH-NCRR [CJX1-443835-WS-29646]
- NSF Major Research Instrumentation grant [CHE-0722519]
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Hypertrophic scarring is a major postoperative complication which leads to severe disfigurement and dysfunction in patients and usually requires multiple surgical revisions due to its high recurrence rates. Excessive-mechanical-loading across wounds is an important initiator of hypertrophic scarring formation. In this study, we demonstrate that intradermal administration of a single extracellular matrix (ECM) molecule-fibromodulin (FMOD) protein-can significantly reduce scar size, increase tensile strength, and improve dermal collagen architecture organization in the normal and even excessive-mechanical-loading red Duroc pig wound models. Since pig skin is recognized by the Food and Drug Administration as the closest animal equivalent to human skin, and because red Duroc pigs show scarring that closely resembles human proliferative scarring and hypertrophic scarring, FMOD-based technologies hold high translational potential and applicability to human patients suffering from scarring-especially hypertrophic scarring.
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