Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 5, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.212548
Keywords
Super-resolution microscopy; Meiosis; Synaptonemal complex; SIM; STORM
Categories
Funding
- Horizon 2020 [634113]
- Vetenskapsradet (Swedish Research Council) [K2013-54X-21397-04-5]
- Cancerfonden (Swedish Cancer Society) [170226]
- Karolinska Institutet
- Hospital Infantil de Mexico [2016-096]
- Programa de Apoyo a Proyectos de Investigacion e Innovacion Tecnologica [IN225917]
- National Microscopy Infrastructure [VR-RFI2016-00968]
- Stiftelsen for Strategisk Forskning (Swedish Foundation for Strategic Research) [RIF14-0091]
- Swedish Foundation for Strategic Research (SSF) [RIF14-0091] Funding Source: Swedish Foundation for Strategic Research (SSF)
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Sexual dimorphism has been used to describe morphological differences between the sexes, but can be extended to any biologically related process that varies between males and females. The synaptonemal complex (SC) is a tripartite structure that connects homologous chromosomes in meiosis. Here, aided by superresolution microscopy techniques, we show that the SC is subject to sexual dimorphism, in mouse germ cells. We have identified a significantly narrower SC in oocytes and have established that this difference does not arise from a different organization of the lateral elements nor from a different isoform of transverse filament protein SYCP1. Instead, we provide evidence for the existence of a narrower central element and a different integration site for the C-termini of SYCP1, in females. In addition to these female-specific features, we speculate that post-translation modifications affecting the SYCP1 coiled-coil region could render a more compact conformation, thus contributing to the narrower SC observed in females.
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