Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 4, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.210450
Keywords
Axon; Electron microscopy; Endoplasmic reticulum; Neuron
Categories
Funding
- Connecticut Science Fund
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The endoplasmic reticulum (ER) is an interconnected network of tubules and sheets. In most tissues of the body, ER tubules have a diameter of similar to 60 nm. Using new methods for serial-section electron microscopy, a distinct class of very narrow, 20-to 30-nm-diameter tubules were found in neurons of both the central and peripheral nervous system. The narrow tubules appear to be the most abundant form of ER in axons, and are also found interspersed in the cell bodies and dendrites. At the site of branch points, there is a small sheet that has a similarly narrow lumen. The narrowness of the ER is likely to be important for the as yet poorly characterized functions of the axonal ER.
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