Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 8, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.196808
Keywords
Axonal mRNA transport; Axonal mRNA translation; RNA granule; Post-transcriptional regulation; Protein synthesis; Ribonucleoprotein particle
Categories
Funding
- National Institutes of Health [R01-NS041596, P01-NS055976, R01-NS089663, R01-NS056314]
- National Science Foundation [MCB-1020970]
- U.S. Department of Defense [W81XWH-13-1-0308]
- Dr Miriam and Sheldon G. Adelson Medical Research Foundation
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Localization and translation of mRNAs within different subcellular domains provides an important mechanism to spatially and temporally introduce new proteins in polarized cells. Neurons make use of this localized protein synthesis during initial growth, regeneration and functional maintenance of their axons. Although the first evidence for protein synthesis in axons dates back to 1960s, improved methodologies, including the ability to isolate axons to purity, highly sensitive RNA detection methods and imaging approaches, have shed new light on the complexity of the transcriptome of the axon and how it is regulated. Moreover, these efforts are now uncovering new roles for locally synthesized proteins in neurological diseases and injury responses. In this Cell Science at a Glance article and the accompanying poster, we provide an overview of how axonal mRNA transport and translation are regulated, and discuss their emerging links to neurological disorders and neural repair.
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