Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 6, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.211904
Keywords
SENP; SUMO; Post-translational modification
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG) collaborative research centers [SFB815, SFB1177]
- LOEWE Ub-Net
- DFG [MU-1764/4]
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The ubiquitin-related SUMO system controls many cellular signaling networks. In mammalian cells, three SUMO forms (SUMO1, SUMO2 and SUMO3) act as covalent modifiers of up to thousands of cellular proteins. SUMO conjugation affects cell function mainly by regulating the plasticity of protein networks. Importantly, the modification is reversible and highly dynamic. Cysteine proteases of the sentrinspecific protease (SENP) family reverse SUMO conjugation in mammalian cells. In this Cell Science at a Glance article and the accompanying poster, we will summarize how the six members of the mammalian SENP family orchestrate multifaceted deconjugation events to coordinate cell processes, such as gene expression, the DNA damage response and inflammation.
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