Journal
JOURNAL OF CELL SCIENCE
Volume 131, Issue 9, Pages -Publisher
COMPANY BIOLOGISTS LTD
DOI: 10.1242/jcs.208884
Keywords
Endocytosis; Galectin; Glycosylation
Categories
Funding
- Agence Nationale pour la Recherche [ANR-14-CE16-0004-03, ANR-14-CE14-0002-02, ANR-16-CE23-0005-02]
- Human Frontier Science Program [RGP0029-2014]
- European Research Council advanced grant [340485]
- European Union program H2020-MSCA-ITN-2014 BIOPOL
- Swedish Research Council
- Deutsche Forschungsgemeinschaft [JA 1033/7, 2213]
- Knut and Alice Wallenberg Foundation [KAW 2013.0022]
- Galecto Biotech AB, Sweden
- European Research Council (ERC) [340485] Funding Source: European Research Council (ERC)
- Agence Nationale de la Recherche (ANR) [ANR-14-CE14-0002, ANR-16-CE23-0005, ANR-14-CE16-0004] Funding Source: Agence Nationale de la Recherche (ANR)
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Galectins are carbohydrate-binding proteins that are involved in many physiological functions, such as inflammation, immune responses, cell migration, autophagy and signalling. They are also linked to diseases such as fibrosis, cancer and heart disease. How such a small family of only 15 members can have such widespread effects remains a conundrum. In this Cell Science at a Glance article, we summarise recent literature on the many cellular activities that have been ascribed to galectins. As shown on the accompanying poster, these include carbohydrate-independent interactions with cytosolic or nuclear targets and carbohydrate-dependent interactions with extracellular glycoconjugates. We discuss how these intra-and extracellular activities might be linked and point out the importance of unravelling molecular mechanisms of galectin function to gain a true understanding of their contributions to the physiology of the cell. We close with a short outlook on the organismal functions of galectins and a perspective on the major challenges in the field.
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