4.7 Review

The cell biology of systemic insulin function

Related references

Note: Only part of the references are listed.
Review Cell Biology

Biochemical and cellular properties of insulin receptor signalling

Rebecca A. Haeusler et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2018)

Article Endocrinology & Metabolism

Insulin uptake and action in microvascular endothelial cells of lymphatic and blood origin

Javier R. Jaldin-Fincati et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2018)

Review Cell Biology

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

Varman T. Samuel et al.

CELL METABOLISM (2018)

Article Endocrinology & Metabolism

Closing in on the Mechanisms of Pulsatile Insulin Secretion

Richard Bertram et al.

DIABETES (2018)

Article Medicine, Research & Experimental

Insulin exits skeletal muscle capillaries by fluid-phase transport

Ian M. Williams et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Neurosciences

Evidence for altered insulin receptor signaling in Alzheimer's disease

Chelsea M. Griffith et al.

NEUROPHARMACOLOGY (2018)

Article Neurosciences

Insulin enhances GABAA receptor-mediated inhibitory currents in rat central amygdala neurons

Sergiy V. Korol et al.

NEUROSCIENCE LETTERS (2018)

Article Endocrinology & Metabolism

Pancreatic neuro-insular network in young mice revealed by 3D panoramic histology

Shiue-Cheng Tang et al.

DIABETOLOGIA (2018)

Article Endocrinology & Metabolism

Human pancreatic neuro-insular network in health and fatty infiltration

Shiue-Cheng Tang et al.

DIABETOLOGIA (2018)

Article Endocrinology & Metabolism

Adapting to insulin resistance in obesity: role of insulin secretion and clearance

Sang-Hee Jung et al.

DIABETOLOGIA (2018)

Article Biochemistry & Molecular Biology

New Roles of Syntaxin-1A in Insulin Granule Exocytosis and Replenishment

Tao Liang et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2017)

Article Medicine, Research & Experimental

Ca2+ channel clustering with insulin-containing granules is disturbed in type 2 diabetes

Nikhil R. Gandasi et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Medicine, Research & Experimental

Discovery, characterization, and clinical development of the glucagon-like peptides

Daniel J. Drucker et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

Insulin action and resistance in obesity and type 2 diabetes

Michael P. Czech

NATURE MEDICINE (2017)

Article Multidisciplinary Sciences

Inositol phosphates and phosphoinositides activate insulin-degrading enzyme, while phosphoinositides also mediate binding to endosomes

Eun Suk Song et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis

Daniel R. Gulbranson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Multidisciplinary Sciences

Endothelial insulin receptors differentially control insulin signaling kinetics in peripheral tissues and brain of mice

Masahiro Konishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Article Biochemistry & Molecular Biology

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking

Maeran Uhm et al.

SCIENCE SIGNALING (2017)

Review Cell Biology

Toward Connecting Metabolism to the Exocytotic Site

Mourad Ferdaoussi et al.

TRENDS IN CELL BIOLOGY (2017)

Review Endocrinology & Metabolism

Update on GLUT4 Vesicle Traffic: A Cornerstone of Insulin Action

Javier R. Jaldin-Fincati et al.

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2017)

Article Cell Biology

Sorting Tubules Regulate Blood-Brain Barrier Transcytosis

Roberto Villasenor et al.

CELL REPORTS (2017)

Article Biochemistry & Molecular Biology

Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking

Maeran Uhm et al.

SCIENCE SIGNALING (2017)

Article Endocrinology & Metabolism

Recruitment of Epac2A to Insulin Granule Docking Sites Regulates Priming for Exocytosis

Ida Alenkvist et al.

DIABETES (2017)

Review Endocrinology & Metabolism

Recent new insights into the role of SNARE and associated proteins in insulin granule exocytosis

Herbert Y. Gaisano

DIABETES OBESITY & METABOLISM (2017)

Article Endocrinology & Metabolism

Unravelling the regulation of insulin transport across the brain endothelial cell

Sarah M. Gray et al.

DIABETOLOGIA (2017)

Review Physiology

Exocytosis proteins as novel targets for diabetes prevention and/or remediation?

Arianne Aslamy et al.

AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY (2017)

Article Cardiac & Cardiovascular Systems

Pathways for insulin access to the brain: the role of the microvascular endothelial cell

Rick I. Meijer et al.

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2016)

Review Biochemistry & Molecular Biology

Spatial and Temporal Regulation of Receptor Tyrosine Kinase Activation and Intracellular Signal Transduction

John J. M. Bergeron et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Article Biochemistry & Molecular Biology

Astrocytic Insulin Signaling Couples Brain Glucose Uptake with Nutrient Availability

Cristina Garcia-Caceres et al.

Article Cell Biology

Beta Cell Hubs Dictate Pancreatic Islet Responses to Glucose

Natalie R. Johnston et al.

CELL METABOLISM (2016)

Editorial Material Endocrinology & Metabolism

Unraveling the Paradox of Selective Insulin Resistance in the Liver: the Brain-Liver Connection

Heather A. Ferris et al.

DIABETES (2016)

Review Medicine, Research & Experimental

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

Varman T. Samuel et al.

JOURNAL OF CLINICAL INVESTIGATION (2016)

Article Endocrinology & Metabolism

Insulin Access to Skeletal Muscle is Impaired During the Early Stages of Diet-Induced Obesity

Josiane L. Broussard et al.

OBESITY (2016)

Review Endocrinology & Metabolism

Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Seung-Hwan Lee et al.

MOLECULAR METABOLISM (2016)

Article Multidisciplinary Sciences

Insulin-induced Effects on the Subcellular Localization of AKT1, AKT2 and AS160 in Rat Skeletal Muscle

Xiaohua Zheng et al.

SCIENTIFIC REPORTS (2016)

Review Physiology

Insulin resistance in chronic kidney disease: a systematic review

Belinda Spoto et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2016)

Article Biochemistry & Molecular Biology

A potential link between insulin signaling and GLUT4 translocation: Association of Rab10-GTP with the exocyst subunit Exoc6/6b

Hiroyuki Sano et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2015)

Article Endocrinology & Metabolism

Tctex1d2 Is a Negative Regulator of GLUT4 Translocation and Glucose Uptake

Yoko Shimoda et al.

ENDOCRINOLOGY (2015)

Article Biochemistry & Molecular Biology

Acetylation of TUG Protein Promotes the Accumulation of GLUT4 Glucose Transporters in an Insulin-responsive Intracellular Compartment

Jonathan P. Belman et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Editorial Material Medicine, Research & Experimental

cAMP-independent effects of GLP-1 on β cells

Jelena Kolic et al.

JOURNAL OF CLINICAL INVESTIGATION (2015)

Review Biochemistry & Molecular Biology

Pulsatile insulin secretion, impaired glucose tolerance and type 2 diabetes

Leslie S. Satin et al.

MOLECULAR ASPECTS OF MEDICINE (2015)

Article Medicine, General & Internal

Type 2 diabetes mellitus

Ralph A. DeFronzo et al.

NATURE REVIEWS DISEASE PRIMERS (2015)

Review Cell Biology

Signal transduction meets vesicle traffic: the software and hardware of GLUT4 translocation

Amira Klip et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Review Cell Biology

Calcium signaling in insulin action on striated muscle

A. Contreras-Ferrat et al.

CELL CALCIUM (2014)

Article Endocrinology & Metabolism

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

Andre Kleinridders et al.

DIABETES (2014)

Article Biochemistry & Molecular Biology

Mitochondrial Metabolism of Pyruvate Is Essential for Regulating Glucose-stimulated Insulin Secretion

Jessica N. Patterson et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Medicine, Research & Experimental

SORCS1 is necessary for normal insulin secretory granule biogenesis in metabolically stressed β cells

Melkam A. Kebede et al.

JOURNAL OF CLINICAL INVESTIGATION (2014)

Article Cell Biology

A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes

Sheelarani Karunanithi et al.

MOLECULAR BIOLOGY OF THE CELL (2014)

Article Cell Biology

Insulin Receptor Signaling in Normal and Insulin-Resistant States

Jeremie Boucher et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2014)

Article Multidisciplinary Sciences

Contact-induced clustering of syntaxin and munc18 docks secretory granules at the exocytosis site

Nikhil R. Gandasi et al.

NATURE COMMUNICATIONS (2014)

Article Endocrinology & Metabolism

Local NOS inhibition impairs vascular and metabolic actions of insulin in rat hindleg muscle in vivo

Eloise A. Bradley et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)

Review Medicine, Research & Experimental

Insulin signalling to the kidney in health and disease

Lorna J. Hale et al.

CLINICAL SCIENCE (2013)

Article Cell Biology

Insulin responsiveness of glucose transporter 4 in 3T3-L1 cells depends on the presence of sortilin

Guanrong Huang et al.

MOLECULAR BIOLOGY OF THE CELL (2013)

Review Transplantation

The biological consequence of obesity on the kidney

Keizo Kanasaki et al.

NEPHROLOGY DIALYSIS TRANSPLANTATION (2013)

Article Multidisciplinary Sciences

Munc18c in Adipose Tissue Is Downregulated in Obesity and Is Associated with Insulin

Lourdes Garrido-Sanchez et al.

PLOS ONE (2013)

Article Physiology

Frequency-dependent mitochondrial Ca2+ accumulation regulates ATP synthesis in pancreatic β cells

Andrei I. Tarasov et al.

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY (2013)

Review Endocrinology & Metabolism

Insulin and glucagon signaling in the central nervous system

Beatrice M. Filippi et al.

REVIEWS IN ENDOCRINE & METABOLIC DISORDERS (2013)

Review Multidisciplinary Sciences

Pleiotropic Actions of Insulin Resistance and Inflammation in Metabolic Homeostasis

Justin I. Odegaard et al.

SCIENCE (2013)

Review Biochemistry & Molecular Biology

Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells

Michael A. Kalwat et al.

EXPERIMENTAL AND MOLECULAR MEDICINE (2013)

Article Endocrinology & Metabolism

Insulin stimulates fusion, but not tethering, of GLUT4 vesicles in skeletal muscle of HA-GLUT4-GFP transgenic mice

Vladimir A. Lizunov et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Article Endocrinology & Metabolism

Deletion of Rab GAP AS160 modifies glucose uptake and GLUT4 translocation in primary skeletal muscles and adipocytes and impairs glucose homeostasis

Melissa N. Lansey et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2012)

Review Biochemistry & Molecular Biology

Regulation of Glucose Transporter Translocation in Health and Diabetes

Jonathan S. Bogan

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 81 (2012)

Review Biochemistry & Molecular Biology

Mechanisms for Insulin Resistance: Common Threads and Missing Links

Varman T. Samuel et al.

Article Cell Biology

Regulation of calcium in pancreatic α- and β-cells in health and disease

Patrik Rorsman et al.

CELL CALCIUM (2012)

Article Cell Biology

Regulation of ATP production by mitochondrial Ca2+

Andrei I. Tarasov et al.

CELL CALCIUM (2012)

Article Endocrinology & Metabolism

Pulsatile Portal Vein Insulin Delivery Enhances Hepatic Insulin Action and Signaling

Aleksey V. Matveyenko et al.

DIABETES (2012)

Article Endocrinology & Metabolism

Insulin entry into muscle involves a saturable process in the vascular endothelium

S. Majumdar et al.

DIABETOLOGIA (2012)

Article Biochemistry & Molecular Biology

Endoproteolytic Cleavage of TUG Protein Regulates GLUT4 Glucose Transporter Translocation

Jonathan S. Bogan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

Article Cell Biology

Myo1c binding to submembrane actin mediates insulin-induced tethering of GLUT4 vesicles

Shlomit Boguslavsky et al.

MOLECULAR BIOLOGY OF THE CELL (2012)

Review Cell Biology

Regulation of glucose transport by insulin: traffic control of GLUT4

Dara Leto et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Physiology

The Barrier Within: Endothelial Transport of Hormones

Cathryn M. Kolka et al.

PHYSIOLOGY (2012)

Article Biochemistry & Molecular Biology

Endocytosis, Recycling, and Regulated Exocytosis of Glucose Transporter 4

Kevin Foley et al.

BIOCHEMISTRY (2011)

Review Cell Biology

Hormonal Regulation of Hepatic Glucose Production in Health and Disease

Hua V. Lin et al.

CELL METABOLISM (2011)

Review Cell Biology

Rac1 signalling towards GLUT4/glucose uptake in skeletal muscle

Tim T. Chiu et al.

CELLULAR SIGNALLING (2011)

Article Endocrinology & Metabolism

The story of insulin discovery

Dimitrios T. Karamitsos

DIABETES RESEARCH AND CLINICAL PRACTICE (2011)

Article Biochemistry & Molecular Biology

Insulin-stimulated GLUT4 Protein Translocation in Adipocytes Requires the Rab10 Guanine Nucleotide Exchange Factor Dennd4C

Hiroyuki Sano et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Cell Biology

Dual-mode of insulin action controls GLUT4 vesicle exocytosis

Yingke Xu et al.

JOURNAL OF CELL BIOLOGY (2011)

Article Cell Biology

GLUT4 exocytosis

Jacqueline Stoeckli et al.

JOURNAL OF CELL SCIENCE (2011)

Article Cell Biology

The Sugar Is sIRVed: Sorting Glut4 and Its Fellow Travelers

Konstantin V. Kandror et al.

TRAFFIC (2011)

Article Cell Biology

SNARE Proteins Underpin Insulin-Regulated GLUT4 Traffic

Nia J. Bryant et al.

TRAFFIC (2011)

Article Neurosciences

DOC2B, C2 Domains, and Calcium: A Tale of Intricate Interactions

Reut Friedrich et al.

MOLECULAR NEUROBIOLOGY (2010)

Article Multidisciplinary Sciences

Rab8A and Rab13 are activated by insulin and regulate GLUT4 translocation in muscle cells

Yi Sun et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Endocrinology & Metabolism

Obesity Blunts Microvascular Recruitment in Human Forearm Muscle After a Mixed Meal

Michelle A. Keske et al.

DIABETES CARE (2009)

Article Cell Biology

Identification of a Distal GLUT4 Trafficking Event Controlled by Actin Polymerization

Jamie A. Lopez et al.

MOLECULAR BIOLOGY OF THE CELL (2009)

Article Multidisciplinary Sciences

The atypical kinase Cdk5 is activated by insulin, regulates the association between GLUT4 and E-Syt1, and modulates glucose transport in 3T3-L1 adipocytes

Vasiliki Lalioti et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

K. Lemaire et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)

Article Multidisciplinary Sciences

A Role for the CHC22 Clathrin Heavy-Chain Isoform in Human Glucose Metabolism

Stephane Vassilopoulos et al.

SCIENCE (2009)

Article Endocrinology & Metabolism

Control of insulin granule dynamics by AMPK dependent KLC1 phosphorylation

Angela McDonald et al.

ISLETS (2009)

Article Physiology

Insulin uptake across the luminal membrane of the rat proximal tubule in vivo and in vitro

Pavel Kolman et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2009)

Article Cell Biology

Myosin light chain kinase activation and calcium sensitization in smooth muscle in vivo

Yusuke Mizuno et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2008)

Article Biochemistry & Molecular Biology

Rab10 in insulin-stimulated GLUT4 translocation

Hiroyuki Sano et al.

BIOCHEMICAL JOURNAL (2008)

Review Biochemistry & Molecular Biology

Glucose regulation of insulin gene expression in pancreatic beta-cells

Sreenath S. Andrali et al.

BIOCHEMICAL JOURNAL (2008)

Article Cell Biology

IRS1-independent defects define major nodes of insulin resistance

Kyle L. Hoehn et al.

CELL METABOLISM (2008)

Article Endocrinology & Metabolism

Effect of Endothelium-Specific Insulin Resistance on Endothelial Function In Vivo

Edward R. Duncan et al.

DIABETES (2008)

Article Endocrinology & Metabolism

Insulin signaling stimulates insulin transport by bovine aortic endothelial cells

Hong Wang et al.

DIABETES (2008)

Article Biochemistry & Molecular Biology

High circulating leptin receptors with normal leptin sensitivity in liver-specific insulin receptor knock-out (LIRKO) mice

Shmuel E. Cohen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2007)

Article Biochemistry & Molecular Biology

Rabs 8A and 14 are targets of the insulin-regulated Rab-GAP AS160 regulating GLUT4 traffic in muscle cells

Shuhei Ishikura et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Review Cell Biology

Critical nodes in signalling pathways: insights into insulin action

CM Taniguchi et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2006)

Article Cell Biology

GLUT4 is retained by an intracellular cycle of vesicle formation and fusion with endosomes

O Karylowski et al.

MOLECULAR BIOLOGY OF THE CELL (2004)

Article Endocrinology & Metabolism

Synchronization and entrainment of cytoplasmic Ca2+ oscillations in cell clusters prepared from single or multiple mouse pancreatic islets

M Zarkovic et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2004)

Review Endocrinology & Metabolism

Insulin granule dynamics in pancreatic beta cells

P Rorsman et al.

DIABETOLOGIA (2003)

Article Endocrinology & Metabolism

Inhibiting NOS blocks microvascular recruitment and blunts muscle glucose uptake in response to insulin

MA Vincent et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2003)

Article Medicine, Research & Experimental

The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance

D Vicent et al.

JOURNAL OF CLINICAL INVESTIGATION (2003)

Article Biochemistry & Molecular Biology

Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation

H Sano et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

W Farris et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Medicine, General & Internal

Transcapillary insulin transfer in human skeletal muscle

H Herkner et al.

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION (2003)

Review Pharmacology & Pharmacy

Insulin and the blood-brain barrier

SC Woods et al.

CURRENT PHARMACEUTICAL DESIGN (2003)

Review Endocrinology & Metabolism

Regulation of insulin action by CEACAM1

SM Najjar

TRENDS IN ENDOCRINOLOGY AND METABOLISM (2002)

Article Genetics & Heredity

CEACAM1 regulates insulin clearance in liver

MN Poy et al.

NATURE GENETICS (2002)

Article Endocrinology & Metabolism

Direct measurement of pulsatile insulin secretion from the portal vein in human subjects

SH Song et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2000)

Review Cell Biology

Mechanism and regulation of GLUT-4 vesicle fusion in muscle and fat cells

LJ Foster et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2000)

Article Multidisciplinary Sciences

Role of brain insulin receptor in control of body weight and reproduction

JC Brüning et al.

SCIENCE (2000)

Review Multidisciplinary Sciences

Central nervous system control of food intake

MW Schwartz et al.

NATURE (2000)

Article Endocrinology & Metabolism

Overnight inhibition of insulin secretion restores pulsatility and proinsulin/insulin ratio in type 2 diabetes

T Laedtke et al.

AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2000)