Related references
Note: Only part of the references are listed.FLCN: The causative gene for Birt-Hogg-Dube syndrome
Laura S. Schmidt et al.
GENE (2018)
Architecture of the human GATOR1 and GATOR1-Rag GTPases complexes
Kuang Shen et al.
NATURE (2018)
Intersubunit Crosstalk in the Rag GTPase Heterodimer Enables mTORC1 to Respond Rapidly to Amino Acid Availability
Kuang Shen et al.
MOLECULAR CELL (2017)
Hybrid Structure of the RagA/C-Ragulator mTORC1 Activation Complex
Ming-Yuan Su et al.
MOLECULAR CELL (2017)
Transcriptional activation of RagD GTPase controls mTORC1 and promotes cancer growth
Chiara Di Malta et al.
SCIENCE (2017)
Structural basis for Ragulator functioning as a scaffold in membrane-anchoring of Rag GTPases and mTORC1
Tianlong Zhang et al.
NATURE COMMUNICATIONS (2017)
Structural basis for the assembly of the Ragulator-Rag GTPase complex
Ryo Yonehara et al.
NATURE COMMUNICATIONS (2017)
Feedback Inhibition of the Rag GTPase GAP Complex Lst4-Lst7 Safeguards TORC1 from Hyperactivation by Amino Acid Signals
Marie-Pierre Peli-Gulli et al.
CELL REPORTS (2017)
The Dawn of the Age of Amino Acid Sensors for the mTORC1 Pathway
Rachel L. Wolfson et al.
CELL METABOLISM (2017)
mTOR Signaling in Growth, Metabolism, and Disease
Robert A. Saxton et al.
CELL (2017)
Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation
Qin Xia et al.
HUMAN MOLECULAR GENETICS (2016)
METABOLISM Sestrin2 is a leucine sensor for the mTORC1 pathway
Rachel L. Wolfson et al.
SCIENCE (2016)
An Ancient, Unified Mechanism for Metformin Growth Inhibition in C. elegans and Cancer
Lianfeng Wu et al.
CELL (2016)
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Lynne Chantranupong et al.
CELL (2016)
Folliculin directs the formation of a Rab34-RILP complex to control the nutrient-dependent dynamic distribution of lysosomes
Georgina P. Starling et al.
EMBO REPORTS (2016)
GATOR1 complex: the common genetic actor in focal epilepsies
Sara Baldassari et al.
JOURNAL OF MEDICAL GENETICS (2016)
C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling
Joseph Amick et al.
MOLECULAR BIOLOGY OF THE CELL (2016)
Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA
Christopher D. Richardson et al.
NATURE BIOTECHNOLOGY (2016)
Amino Acids Stimulate TORC1 through Lst4-Lst7, a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr2
Marie-Pierre Peli-Gulli et al.
CELL REPORTS (2015)
Lst4, the yeast Fnip1/2 orthologue, is a DENN-family protein
Angela Pacitto et al.
OPEN BIOLOGY (2015)
Sestrin2 inhibits mTORC1 through modulation of GATOR complexes
Jeong Sig Kim et al.
SCIENTIFIC REPORTS (2015)
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome
Suchithra Menon et al.
CELL (2014)
The Nutrient-Responsive Transcription Factor TFE3 Promotes Autophagy, Lysosomal Biogenesis, and Clearance of Cellular Debris
Jose A. Martina et al.
SCIENCE SIGNALING (2014)
The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1
Lynne Chantranupong et al.
CELL REPORTS (2014)
Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex
Anita Parmigiani et al.
CELL REPORTS (2014)
Enhanced homology-directed human genome engineering by controlled timing of CRISPR/Cas9 delivery
Steven Lin et al.
ELIFE (2014)
The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
Timothy P. Levine et al.
BIOINFORMATICS (2013)
Recruitment of folliculin to lysosomes supports the amino acid-dependent activation of Rag GTPases
Constance S. Petit et al.
JOURNAL OF CELL BIOLOGY (2013)
Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes
Jose A. Martina et al.
JOURNAL OF CELL BIOLOGY (2013)
The Folliculin Tumor Suppressor Is a GAP for the RagC/D GTPases That Signal Amino Acid Levels to mTORC1
Zhi-Yang Tsun et al.
MOLECULAR CELL (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
REGULATION OF SMALL GTPases BY GEFs, GAPs, AND GDIs
Jacqueline Cherfils et al.
PHYSIOLOGICAL REVIEWS (2013)
A Tumor Suppressor Complex with GAP Activity for the Rag GTPases That Signal Amino Acid Sufficiency to mTORC1
Liron Bar-Peled et al.
SCIENCE (2013)
Amino Acid Deprivation Inhibits TORC1 Through a GTPase-Activating Protein Complex for the Rag Family GTPase Gtr1
Nicolas Panchaud et al.
SCIENCE SIGNALING (2013)
Ragulator Is a GEF for the Rag GTPases that Signal Amino Acid Levels tomTORC1
Liron Bar-Peled et al.
CELL (2012)
The Transcription Factor TFEB Links mTORC1 Signaling to Transcriptional Control of Lysosome Homeostasis
Agnes Roczniak-Ferguson et al.
SCIENCE SIGNALING (2012)
Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer
Ravi K. Nookala et al.
OPEN BIOLOGY (2012)
Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
Dapeng Zhang et al.
Frontiers in Genetics (2012)
Crystal structure of the Gtr1p-Gtr2p complex reveals new insights into the amino acid-induced TORC1 activation
Rui Gong et al.
GENES & DEVELOPMENT (2011)
DENN Domain Proteins: Regulators of Rab GTPases
Andrea L. Marat et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Insights regarding guanine nucleotide exchange from the structure of a DENN-domain protein complexed with its Rab GTPase substrate
Xudong Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors
Shin-ichiro Yoshimura et al.
JOURNAL OF CELL BIOLOGY (2010)
The Connecdenn DENN Domain: A GEF for Rab35 Mediating Cargo-Specific Exit from Early Endosomes
Patrick D. Allaire et al.
MOLECULAR CELL (2010)
Identification and characterization of a novel folliculin-interacting protein FNIP2
Hisashi Hasumi et al.
GENE (2008)
Regulation of TORC1 by Rag GTPases in nutrient response
Eunjung Kim et al.
NATURE CELL BIOLOGY (2008)
Interaction of folliculin (Birt-Hogg-Dube gene product) with a novel Fnip1-like (FnipL/Fnip2) protein
Y. Takagi et al.
ONCOGENE (2008)
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
Yasemin Sancak et al.
SCIENCE (2008)
GEFs and GAPs: Critical elements in the control of small G proteins
Johannes L. Bos et al.
CELL (2007)
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
Masaya Baba et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Lentivirus-delivered stable gene silencing by RNAi in primary cells
SA Stewart et al.
RNA (2003)
Mutations in a novel gene lead to kidney tumors, lung wall defects, and benign tumors of the hair follicle in patients with the Birt-Hogg-Dube syndrome
ML Nickerson et al.
CANCER CELL (2002)
Novel G proteins, Rag C and Rag D, interact with GTP-binding proteins, Rag A and Rag B
T Sekiguchi et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Share Paper
