Journal
JOURNAL OF CATALYSIS
Volume 365, Issue -, Pages 36-42Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jcat.2018.06.013
Keywords
Modulation synthesis; Defect; Zr-MOFs; L-proline; Aldol reaction
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Funding
- Chinese Scholarship Council (CSC)
- Ghent University BOF
- Ghent University
- FWO [PEGASUS]2 Marie Sklodowska-Curie [665501]
- Flemish (VLAIO) [150663]
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Three L-proline modulated zirconium based MOFs denoted as UiO-66, Zr-NDC (NDC = 2,6-Naphthalene dicarboxylate) and UiO-67 were synthesized, characterized and explored as heterogeneous catalyst in diastereoselective aldol addition reactions between 4-nitrobenzaldehyde and linear/cyclic ketones. Upon L-proline modulation, chirality was introduced into these Zr-MOFs which were consequently explored as chiral catalysts for asymmetric reactions. A systematic study was conducted to look into the effect of the synthesis temperature on the modulation in each Zr-MOF. The modulated UiO-66 material synthesized at 120 degrees C exhibited full conversion and a good diastereoselectivity whereas the homogeneous L-proline catalyst showed only 61% conversion and a reversed diastereoselectivity. The catalyst exhibited no leaching of the catalytically active species and was reused for at least three additional cycles. The observed high catalytic activity is a result of the electron withdrawing nature of the Zr-node coordinated to L-proline. (C) 2018 Elsevier Inc. All rights reserved.
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