Journal
JOURNAL OF BIOPHOTONICS
Volume 11, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201700358
Keywords
brain implant; neuroprosthesis; optoelectronics; optogenetics; optrode; prosthesis
Categories
Funding
- Wellcome Trust [102037/Z/13/Z]
- Seventh Framework Programme [24986]
- Engineering and Physical Sciences Research Council [NS/A000026/1]
- Wellcome Trust
- European Commission
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Implantable photonic probes are of increasing interest to the field of biophotonics and in particular, optogenetic neural stimulation. Active probes with onboard light emissive elements allow for electronic multiplexing and can be manufactured through existing microelectronics methods. However, as the optogenetics field moves towards clinical practice, an important question arises as to whether such probes will cause excessive thermal heating of the surrounding tissue. Light emitting diodes typically produce more heat than light. The resultant temperature rise of the probe surface therefore needs to be maintained under the regulatory limit of 2 degrees C. This work combines optical and thermal modelling, which have been experimental verified. Analysis has been performed on the effect of probe/emitter geometries, emitter, and radiance requirements. Finally, the effective illumination volume has been calculated within thermal limits for different probe emitter types and required thresholds.
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