Journal
JOURNAL OF BIOPHOTONICS
Volume 11, Issue 9, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/jbio.201800021
Keywords
molecular imaging; prostate-specific membrane antigen; spectroscopic photoacoustic imaging
Categories
Funding
- National Institutes of Health (US) [CA202199, EB015638, CA134675]
- National Science Foundation (US) [1653322]
- Div Of Information & Intelligent Systems
- Direct For Computer & Info Scie & Enginr [1653322] Funding Source: National Science Foundation
Ask authors/readers for more resources
A sensitive, noninvasive method to detect localized prostate cancer, particularly for early detection and repetitive study in patients undergoing active surveillance, remains an unmet need. Here, we propose a molecular photoacoustic (PA) imaging approach by targeting the prostate-specific membrane antigen (PSMA), which is over-expressed in the vast majority of prostate cancers. We performed spectroscopic PA imaging in an experimental model of prostate cancer, namely, in immunocompromised mice bearing PSMA+ (PC3 PIP) and PSMA- (PC3 flu) tumors through administration of the known PSMA-targeted fluorescence agent, YC-27. Differences in contrast between PSMA+ and isogenic control tumors were observed upon PA imaging, with PSMA+ tumors showing higher contrast in average of 66.07-fold with 5 mice at the 24-hour postinjection time points. These results were corroborated using standard near-infrared fluorescence imaging with YC-27, and the squared correlation between PA and fluorescence intensities was 0.89. Spectroscopic PA imaging is a new molecular imaging modality with sufficient sensitivity for targeting PSMA in vivo, demonstrating the potential applications for other saturable targets relevant to cancer and other disorders.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available