Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 23, Issue 4, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.23.4.045001
Keywords
oral lichen planus; saliva; terahertz time-domain spectroscopy; chemometrics; exfoliative cytology
Funding
- Russian Foundation for Basic Research [17-00-00186]
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The ability to diagnose oral lichen planus (OLP) based on saliva analysis using THz time-domain spectroscopy and chemometrics is discussed. The study involved 30 patients (2 male and 28 female) with OLP. This group consisted of two subgroups with the erosive form of OLP (n = 15) and with the reticular and papular forms of OLP (n = 15). The control group consisted of six healthy volunteers (one male and five females) without inflammation in the mucous membrane in the oral cavity and without periodontitis. Principal component analysis was used to reveal informative features in the experimental data. The one-versusone multiclass classifier using support vector machine binary classifiers was used. The two-stage classification approach using several absorption spectra scans for an individual saliva sample provided 100% accuracy of differential classification between OLP subgroups and control group. (C) 2018 Society of Photo-Optical Instrumentation Engineers (SPIE)
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